The High Throughput Genomics Core (HTGC) for clinical and translation medicine is a CAP/CLIA-certified state of the art genomics facility located in the center of Shadyside in Pittsburgh, PA. The facility houses a high-throughput, clinical-grade, 9,000 ft² next generation sequencing (NGS) laboratory with an integrated bioinformatics cloud infrastructure. The HTGC staff includes two laboratory directors, laboratory staff, bioinformaticians, and IT support personnel. 

The HTGC provides numerous laboratory and data analysis services to local research, commercial, and clinical interests. Our flexible, modular approach to project management allows samples to enter and leave the workflow at any stage, so investigators requisition only the services they require. Some clients complete highly customized portions of an experiment at their own or other facilities while realizing significant cost savings by completing sequencing and analysis at the HTGC. The HTGC works closely with UPMC in addition to other University of Pittsburgh’s genetics core laboratories to facilitate inter-lab sample transfer and batching to maximize efficiency and minimize cost for these projects. Other clients utilize our end-to-end workflow beginning with nucleic acid extraction and ending with comprehensive bioinformatics analysis or clinical reporting, including customizations available throughout the process. In other cases, we generate clinical-grade data for downstream analysis and treatment decision-making by collaborators.